Crescentic Glomerulonephritis in Children

Children’s Hospitals house the largest registry in the world for crescentic glomerulonephritis; extensive research underway.


The pediatric nephrology program at Hackensack Meridian Joseph M. Sanzari Children’s Hospital and K. Hovnanian Children’s Hospital plays a critical role in understanding and improving outcomes for children with renal disease—making both children’s hospitals the clinical coordinating centers for the world’s largest registry for crescentic glomerulonephritis. The registry is expected to become an international registry soon and will deliver significant novel discoveries around crescentic glomerulonephritis in the coming years.

Through the clinical research registry and ongoing study of crescentic glomerulonephritis, pediatric nephrology specialists have discovered that pediatric patients with glomerulonephritis and crescents have multiple risk factors that lead to dialysis, and that for each 1% increase in the percentage of crescents, they have a 3% decrease in log odds of 1-year renal survival, and a 2% decrease in log odds of renal survival at last follow-up (3 years).

Guillermo Hidalgo, M.D., pediatric nephrologist at K. Hovnanian Children’s Hospital, and his co-investigators are actively leading investigations on the causes of crescentic glomerulonephritis by different etiologies. They hope to identify risk factors associated with poor outcomes and treatments that are associated with improved long-term clinical outcomes.

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