Hackensack Meridian Health Joseph M. Sanzari Children’s Hospital Researching Better Treatments for Solid Tumors in Children


Several Transdisciplinary and Interinstitutional Efforts Offer Promise

Collaborations are driving research success for Hackensack Meridian Health’s pediatric solid tumor specialists, with several key initiative underway.

In November 2019, The St. Baldrick’s Foundation, the largest private funder of childhood cancer research grants, awarded Katharine Offer, M.D. of the Children’s Cancer Institute of Hackensack Meridian Health Joseph M. Sanzari Children’s Hospital an infrastructure grant. The grant is focused on enabling Dr. Offer to open, coordinate and treat more children on clinical trials for solid tumors, notably sarcomas.

Dr. Offer is collaborating with the Zilberberg Lab at the Hackensack Meridian Health Center for Discovery and Innovation to study the bone sarcoma microenvironment – in large part due to a $10,000 grant from The Swartz Foundation.

The Zilberberg lab has undertaken the challenge of developing technologies to reproduce the bone/bone marrow microenvironment of multiple myeloma, as well as other malignancies that reside in, or metastasize to, the bone marrow niche.

The Children’s Cancer Institute at Joseph M. Sanzari Children’s Hospital will be studying bone metabolism in pediatric bone sarcomas based on review of pediatric osteosarcomas and Ewing sarcomas treated at the Children’s Hospital.

New to the Pediatric Oncology Division of K. Hovnanian Children’s Hospital, Andrew Silverman, M.D., is completing investigating differences in the immune infiltrative patterns of patients whose tumors responded to immunotherapy, as opposed to those whose tumors did not.