ZUMA-1 Five-Year Follow-Up Shows Axicabtagene Ciloleucel Treatment Success for Refractory Large B-Cell Lymphoma

John Theurer Cancer Center at Hackensack University Medical Center researchers assess outcomes for aggressive B-cell lymphoma treatment

A five-year follow-up of ZUMA-1 trial participants supports the curative potential of axicabtagene ciloleucel (axi-cel) autologous anti-CD19 chimeric antigen receptor (CAR) T-Cell therapy in refractory large B-cell lymphoma. Researchers at John Theurer Cancer Center at Hackensack University Medical Center contributed to the study, with several notable findings:

• Five-year follow-up analysis demonstrates sustained overall and disease-specific survival, with no new safety signals in patients with refractory LBCL. 
• Protracted B-cell aplasia was not required for durable responses. 
• Axi-cel holds curative potential in a subset of patients with aggressive large B-cell lymphomas. 

Investigator-assessed response, survival, safety and pharmacokinetics were analyzed in patients who received treatment in the ZUMA-1 trial. No new serious adverse events or deaths related to axi-cel were observed after additional follow-up. 

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